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Name/scientific name |
TISAGENLECLEUCEL
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Self-financed or subsidized by the Hospital Authority |
Hospital Authority Drug Formulary
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Indications |
acute lymphoblastic leukemia, non-Hodgkin's large B-cell lymphoma
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Tisagenlecleucel (Tisagenlecleucel) is a CAR-T cell therapy used to treat a specific type of B-cell lymphoma. This treatment works by extracting a patient's immune cells, modifying them to attack cancer cells, and then reinjecting them into the patient's body. This helps strengthen the patient's immune system to fight cancer.
Tisagenlecleucel has been shown to have significant efficacy in some patients with B-cell lymphomas, including DLBCL and B-cell acute lymphoblastic leukemia. The treatment process may be accompanied by some serious side effects, such as cell activation syndrome and neurotoxicity. Therefore, patients require close monitoring and management while receiving this treatment.
In Hong Kong, tisagenlecleucel may be used as a treatment option for certain B-cell lymphomas, but patients should receive treatment under professional medical guidance and undergo regular evaluation and monitoring.
HOW TO USE: Make sure you are using this medication in a professional medical setting. The drug will be given to the patient via intravenous injection and must be administered by a professional medical professional. While receiving treatment, patients need to monitor their condition closely for possible side effects or reactions. Patients may need to stay in the hospital for observation after treatment to ensure that their body adjusts to the medication.
Dosing Guidelines: For adult patients, the generally recommended starting dose is 200 million to 600 million CAR-T cells per kilogram of body weight. The dosage may be adjusted based on the patient's specific condition, and the physician will determine the most appropriate dosage based on the patient's physical condition and disease severity. For pediatric patients, the dosage may vary, and the physician will determine the appropriate dosage based on factors such as the child's age and weight. Patients should closely follow their physician's advice after receiving treatment and have regular check-ups to monitor treatment effects and possible side effects.
Tisagenlecleucel is a CAR-T cell therapy used to treat certain types of leukemia and lymphoma. This treatment can cause serious side effects, including high fever, low blood pressure, difficulty breathing, neurological problems and impaired kidney function. Some patients may also experience severe allergic reactions, such as anaphylactic shock. Other common side effects include headache, vomiting, muscle pain and infection. If you notice any unusual body reactions, report them to your doctor immediately. Physical condition needs to be closely monitored during treatment to ensure that any side effects are dealt with promptly.
Drug name: Tisagenlecleucel
Contraindications:
1. It is prohibited to use if you are allergic to tisagenlecleucel or any ingredients.
2. Patients who have received other CAR-T cell therapies or other gene therapies are not suitable for use of tisagenlecleucel.
3. Pregnant and lactating women should not use this drug and should use it with caution under the guidance of a physician.
4. Children and teenagers (under 18 years old) need to consult a doctor whether it is suitable for use and are not allowed to use it by themselves.
Precautions:
1. Before using tisagenlecleucel, patients need to undergo a comprehensive physical examination and evaluation to ensure that their physical condition is suitable for CAR-T cell therapy.
2. Serious side effects may occur during use, such as fever, hypotension, difficulty breathing, etc. Patients should be closely observed and seek medical attention immediately.
3. During treatment, patients should avoid receiving live vaccines to avoid affecting the treatment effect and increasing risks.
4. The long-term effects and safety require further research. Patients should receive regular follow-up examinations from doctors to ensure treatment effects and physical health.
The above are the contraindications and precautions for Tisagenlecleucel. Patients should read the instructions carefully before use and use it under the guidance of a physician to ensure safe and effective treatment.
Precautions for use of TISAGENLECLEUCEL: This drug is a CAR-T cell therapy and is only suitable for the treatment of specific types of B-cell leukemias and lymphomas. Consult a professional physician before use and strictly follow the treatment plan and medical instructions. Serious side effects may occur during treatment, including allergic reactions, neurological problems, and immune reactions, and patients need to be closely monitored.
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Pregnant women should be careful when using salary increase deposits. It's not clear whether this drug, used to treat certain types of leukemia and lymphoma, poses a risk to pregnant women and their fetuses. Avoid using paycheck deposits during pregnancy unless specifically directed by your doctor. If you are planning to become pregnant or suspect that you are pregnant, you should tell your doctor immediately. During the period of using salary increase deposit, effective contraceptive measures should be used to avoid unwanted pregnancy. If you find out that you are pregnant while taking Salary Booster, you should contact your doctor immediately. A doctor will assess the risks and benefits and provide appropriate advice. Remember, any medication should be used with caution during pregnancy to ensure the safety and health of mother and fetus.
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