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project

Name/scientific name

MITOTANE

Self-financed or subsidized by the Hospital Authority

Hospital Authority Drug Formulary

Indications

adrenocortical carcinoma

body system

Cancer and immune system

type 

Cytotoxic drugs

Drug introduction

Mitotane (mitomezole) is a drug used to treat adrenocortical adenomas and hyperadrenocorticism. It is often used as an adjunctive treatment to help control the symptoms and progression of these diseases. Mitotane's mechanism of action is to inhibit the function of the adrenal cortex, thereby reducing hormone levels. Patients should use this medication strictly according to their doctor's recommendations and dosage. While taking Mitotane, patients will need regular blood tests and monitoring to ensure safety and effectiveness. Additionally, patients should avoid interactions with other medications, especially those that may affect liver function. During the use of Mitotane, some side effects may occur, such as nausea, vomiting, fatigue, etc., and patients should inform their doctor in time. Overall, Mitotane is an effective drug, but patients should use it under the supervision of a doctor to ensure therapeutic efficacy and safety.

Dosage

Instructions for use: Take MITOTANE tablets orally in divided doses daily. Best taken after a meal to help reduce stomach upset. Avoid taking it with high-fat foods to avoid affecting the efficacy of the medicine. While taking it, avoid drinking alcohol and participating in activities that require alertness.

Dosing Guidelines: The usual starting dose for adult patients is 500 mg daily, divided into two doses. The dose may be gradually increased according to physician's instructions, but shall not exceed 6 grams per day. The dosage for pediatric patients is based on weight and severity of the disease and requires precise guidance from a physician. If you have any questions, you should consult your doctor immediately.

side effect

MITOTANE is a drug used to treat adrenocortical cancer, but it has some side effects to be aware of. Common ones include dizziness, nausea, vomiting and loss of appetite. Some patients may also experience skin reactions such as redness, itching or dryness. In addition, MITOTANE may also affect liver function and cause abnormal liver function tests. If you have any uncomfortable feeling or abnormal situation, you should contact your doctor immediately. Before seeing a doctor, remember to explain your medical history and use of other medications to the doctor.

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Taboo

MITOTANE is a drug used to treat adrenocortical carcinoma, but special attention needs to be paid to contraindications when using it. First, MITOTANE is contraindicated in women who are pregnant or may become pregnant because the drug may cause serious harm to the fetus. Secondly, for patients with abnormal liver function or liver disease, MITOTANE should be avoided to avoid aggravating the condition. Also, MITOTANE is contraindicated in patients with severe hyperthyroidism. In addition, patients who are allergic to MITOTANE or drugs of similar structure should avoid using this drug to avoid allergic reactions. While using MITOTANE, patients should be monitored regularly by their physician to ensure the safety and effectiveness of the drug. In short, patients should inform their doctors in detail about their medical history and drug allergies before using MITOTANE to ensure safe use of the drug.

Precautions

Mitotane

Precautions for use: It should only be used under the instructions of your doctor and do not adjust the dosage yourself. Regular blood tests should be performed while taking it to monitor the effects of the drug and possible side effects. If any adverse reactions occur, inform your doctor immediately.

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  • Medication grading for pregnant women

    Mitotane is a drug used to treat chromaffin cell tumors and should be used with caution in women during pregnancy. Women with pheochromocytoma should tell their doctor before becoming pregnant because Mitotane may cause harm to the fetus. Once a patient is determined to be pregnant, she should immediately stop using Mitotane and consult her doctor about appropriate treatment. Women with pheochromocytoma should use effective contraception during treatment to avoid pregnancy. At the same time, patients should avoid becoming pregnant while taking Mitotane until treatment is completed and confirmed by their doctor. If a patient suspects she is pregnant, she should tell her doctor immediately so that necessary tests and evaluations can be done. In summary, Mitotane users should pay attention to contraception and work with their doctor to ensure safety during pregnancy.

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