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project

Name/scientific name

LARONIDASE

Self-financed or subsidized by the Hospital Authority

Hospital Authority Drug Formulary

Indications

Mucopolysaccharidosis type I, Hurler syndrome

body system

type 

Drug introduction

Laronidase (Laronidase) is an enzyme replacement therapy used to treat Mucopolysaccharidosis I (MPS I). MPS I is a rare genetic disorder that causes the body to be unable to metabolize glycoproteins normally. Laronidase helps degrade accumulated glycoproteins in the body by replenishing deficient enzymes, thereby alleviating symptoms and delaying disease progression. People with MPS I may experience a variety of symptoms, including skeletal deformities, organ enlargement, and difficulty breathing.

Laronidase is usually administered through an intravenous drip and needs to be administered under the supervision of a medical professional. During use, some common side effects may occur, such as fever, headache, and rash. Patients should receive regular medical monitoring while using Laronidase to ensure treatment effectiveness and safety.

Please follow your doctor's advice and return for regular check-ups to ensure the effectiveness of your treatment. If you have any questions or concerns, please consult a medical professional.

Dosage

Instructions for use: Ask a professional physician or medical staff to inject in a clinic or hospital. Allergic reactions should be checked before injection and appropriate medical equipment should be ensured. Disinfection procedures must be strictly followed during the injection process and aseptic operation must be ensured. Patients should receive treatment under professional supervision.

Dosing Guidelines: The recommended dose for adults and children is 0.58 mg/kg body weight per week, divided evenly into three divided doses per week. The starting dose should be determined based on the patient's weight and disease severity, and should be adjusted under the guidance of a professional physician. For patients of certain age groups, such as children or adolescents, the dosage may need to be adjusted and physician recommendations should be strictly followed.

The above is information about the use and dosage of LARONIDASE. Please use the drug under professional guidance and do not adjust the dosage or usage by yourself.

side effect

LARONIDASE is a drug used to treat rare genetic diseases, but some side effects may occur when used. Common side effects include fever, headache, nausea, vomiting and skin sensitivity. Rare side effects include allergic reactions, such as skin redness and swelling, difficulty breathing, etc. Some patients may also experience redness, swelling and pain at the injection site. If serious side effects occur, consult your doctor immediately. When using this drug, your physical condition needs to be closely monitored and checked regularly to ensure it is safe and effective.

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Taboo

Drug name: LARONIDASE

Taboo:

1. Patients who are allergic to LARONIDASE or have a history of allergy are prohibited from using it.
2. Pregnant and lactating women should avoid using LARONIDASE as there are insufficient studies to confirm its safety to fetuses or infants.
3. Patients with severe heart disease or cardiovascular system disease should avoid using LARONIDASE to avoid aggravating their condition.
4. Patients who have experienced severe side effects from LARONIDASE in the past should avoid using it again.
5. When using LARONIDASE, you should avoid using it at the same time with specific drugs, such as specific antibiotics or immunosuppressants, and should be used under the guidance of a physician.

The above are the contraindications of LARONIDASE. Please consult a doctor or pharmacist before use to ensure that your personal situation is suitable for using this drug to avoid adverse reactions or dangerous situations.

Precautions

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  • Medication grading for pregnant women

    Pregnant women should avoid using Laronidase. According to research, this drug may cause adverse effects on the fetus and may increase the risk of miscarriage or birth defects.

    Lanozyme should be avoided if you are pregnant or planning to become pregnant. During pregnancy, medications must be chosen carefully to avoid harm to the fetus. If you have a medical condition that requires treatment, be sure to tell your doctor about your pregnancy so that your doctor can find an appropriate alternative prescription medication or treatment for you.

    In summary, lanozyme drugs should be avoided during pregnancy to ensure the safety of mother and baby. If you have any questions or need further information, please consult your doctor or pharmacist immediately. I wish you and your baby good health.

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