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project

Name/scientific name

EPOPROSTENOL

Self-financed or subsidized by the Hospital Authority

Hospital Authority Drug Formulary

Indications

pulmonary hypertension, chronic thromboembolic pulmonary hypertension

body system

cardiology

type 

Anticoagulants and protamine

Drug introduction

Epoprostenol is a synthetic prostaglandin drug used to treat severe pulmonary hypertension. It dilates the pulmonary artery and pulmonary artery branches, thereby reducing pulmonary artery resistance and improving cardiac function and exercise tolerance. Epoprostane is administered intravenously and is usually administered in a hospital or clinic by a professional medical team. Blood pressure, heartbeat and other physiological indicators need to be closely monitored during treatment to ensure safety and effectiveness. In Hong Kong, eprostanin is commonly used for the treatment of severe pulmonary hypertension and should be used according to the advice and prescription of a physician. Patients should closely follow the instructions of their medical professional during use to ensure optimal efficacy and reduce the risk of adverse reactions.

Dosage

Instructions for use: Use EPOPROSTENOL injection intravenously. Before each injection, ensure that the solution is clear and has no significant precipitation or segregation. The injection rate should be based on the patient's tolerance. The initial rate should be 1 to 2 ml per minute and gradually increased to 10 to 20 ml per minute. Adjustment of injection speed should be done under the supervision of a medical professional.

Dosing Guidelines: For adult patients, the initial dose is 1.25 to 2.5 mg every minute every 4 hours. The dose may be adjusted from 2 to 12 mg per minute based on patient tolerance and therapeutic efficacy. For children, the dose should be adjusted based on body weight and severity of symptoms, with an initial dose of 0.03 to 0.05 mg per minute every 4 hours. Physicians should adjust the dose based on the child's specific condition.

During the use of EPOPROSTENOL, patients should avoid excessive activity and high-fat foods, so as not to affect the absorption and effect of the drug. If you have any discomfort or questions, patients should consult a medical professional immediately.

side effect

Epoprostenol is a drug used to treat pulmonary arterial hypertension, but it has some side effects to be aware of. Some patients may experience gastrointestinal problems such as headache, nausea, vomiting or diarrhea after taking it. In addition, some patients may experience hypotension, palpitations, or skin reactions such as skin redness, swelling, and itching. Some patients may also feel tired or have difficulty breathing. If serious side effects occur, consult your doctor immediately. Remember to use the medicine according to the doctor's instructions and do not change the dosage on your own.

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Taboo

Epoprostenol is a drug used to treat severe primary pulmonary hypertension. When using Epoprostenol, patients should pay special attention to the following contraindications:

1. Patients who are allergic to Epoprostenol or to other prostaglandin drugs should not use Epoprostenol because it may cause severe allergic reactions.

2. Pregnant women should avoid using Epoprostenol because the drug may cause harm to the fetus.

3. Patients with heart valve disease, atrial fibrillation or other heart problems should consult a doctor before using Epoprostenol, as these conditions may affect the safety and effectiveness of the drug.

4. Patients who are at risk of bleeding or are receiving anticoagulant therapy should use Epoprostenol with caution as it may increase the risk of bleeding.

5. Patients with hepatic or renal insufficiency should inform their doctor in detail before using Epoprostenol, as this may require dose adjustment or monitoring.

In short, patients should inform their doctors in detail about their health conditions and drug allergies before using Epoprostenol to ensure the safe use of this drug.

Precautions

Iproprost is a drug used to treat severe pulmonary hypertension. Please strictly follow your doctor's instructions when using it, and do not adjust the dosage yourself. Pay close attention to your body's reaction during use, and inform your doctor immediately if you experience any discomfort or abnormalities.

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  • Medication grading for pregnant women

    For pregnant women, epoprostenol should be avoided in pregnant women because there are not enough studies to determine its effects on the fetus. If you are pregnant or planning to become pregnant, be sure to tell your doctor so they can help you find safe alternatives. While you are using epoprostenol, make sure to use good birth control to avoid unwanted pregnancy. Also, if you suspect you are pregnant, you should notify your doctor immediately so possible risks can be assessed and managed. If you have any questions or concerns, please feel free to speak to your doctor and make sure you get the right advice and guidance. Do not stop using epoprostenol or change your treatment plan without first consulting your doctor. The health of you and your baby is the most important, discuss it with your doctor as soon as possible and find the best solution.

    (Note: The information provided is for educational purposes only and should not be considered medical advice. Please consult with your healthcare provider for personalized recommendations.)

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